2'-AMINO-2'-DEOXYNUCLEOSIDES AS INHIBITORS IF MEASLES AND MARBURG VIRUSUS REPRODUCTION

FIELD: organic chemistry, biochemistry, medicine, virology. ^ SUBSTANCE: invention relates to derivatives of 2'=amino-2'-deoxynucleosides of the formula: ^ wherein R means hydrogen atom (H), alkyl, aminoalkyl; R1 means -(R2NR3) wherein R2 and/or R3 means H, -OH, -NH2, alkyl, benzyl under c...

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Hauptverfasser: ALEKSANDROVA L.A, POKROVSKIJ A.G, KUKHANOVA M.K, IL'ICHEVA T.N, BELANOV E.F, VOLKOV G.N
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:FIELD: organic chemistry, biochemistry, medicine, virology. ^ SUBSTANCE: invention relates to derivatives of 2'=amino-2'-deoxynucleosides of the formula: ^ wherein R means hydrogen atom (H), alkyl, aminoalkyl; R1 means -(R2NR3) wherein R2 and/or R3 means H, -OH, -NH2, alkyl, benzyl under condition that R doesn't represent H or methyl when R2 and R3 mean H. Compounds elicit an antiviral activity with respect to measles and Marburg viruses exceeding that of ribavirin. ^ EFFECT: valuable properties of compounds. ^ 4 tbl, 2 dwg, 18 ex