METHOD FOR ISOLATION OF BIOACTIVE FRACTION (BAF) CONTAINING S-LIPOPOLYSACCHARIDES (S-LPS) FROM GRAM-NEGATIVE BACTERIA, BAF FOR PREVENTION AND TREATMENT OF DISEASES INDUCED BY ENDOTOXIC S-LPS PRODUCING GRAM-NEGATIVE BACTERIA, PHARMACEUTICAL COMPOSITION, METHODS FOR INDUCING OF PROTECTIVE IMMUNITY AND IMPROVING STATE IN PATIENT IN NEED OF IMMUNE STATUS INCREASING

FIELD: biotechnology, medicine. ^ SUBSTANCE: invention relates to method for isolation of bioactive fraction (BAF) containing essentially S-lipopolysaccharides (S-LPS) from endotoxic S-LPS producing gram-negative bacteria, useful in prophylaxis and therapy. From endotoxic S-LPS producing gram-negati...

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Hauptverfasser:	GOLOVINA M.EH, ELKINA S.I, APARIN P.G, SHMIGOL' V.I, L'VOV V.L
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology, medicine. ^ SUBSTANCE: invention relates to method for isolation of bioactive fraction (BAF) containing essentially S-lipopolysaccharides (S-LPS) from endotoxic S-LPS producing gram-negative bacteria, useful in prophylaxis and therapy. From endotoxic S-LPS producing gram-negative bacteria BAF is isolated that has in lipid A S-LPS molar ratio of D-glucoseamine and beta-hydroxy acids selected from beta-hydroxydecanic, beta-hydroxydodecanic, beta-hydroxytetradecanic and beta-hydroxyhexadecanic acids of about 2:1-4, and molar ration of D-glucoseamine and high fatty acids connected via either amide or ester bond in lipid A S-LPS of about 2:3-7. Isolated BAF ins used in pharmaceutical composition to increase of patient immune status. ^ EFFECT: method for isolation from gram-negative bacteria bioactive fraction of S-LPS with high immunogenic properties, being capable to induce cytokine production with low pyrogenic and endotoxic properties. ^ 41 cl, 4 dwg, 14 tbl, 24 ex