5-ARYL-1-PHENYL-4-HETEROYL-3-HYDROXY-3-PYRROLINE-2-ONES ELICITING ANTIBACTERIAL ACTIVITY

5-ARYL-1-PHENYL-4-HETEROYL-3-HYDROXY-3-PYRROLINE-2-ONES ELICITING ANTIBACTERIAL ACTIVITY

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to new 5-aryl-1-phenyl-4-heteroyl-3-hydroxy-3-pyrroline-2-ones of the formula: ^ wherein (1) X means sulfur atom (S); R means (CH3)2CH; (2) X means sulfur atom (S); R means (CH3)3C; (3) X means oxygen atom (O); R means (CH...

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Bibliographische Detailangaben
Hauptverfasser: PLATONOV V.S, GEJN L.F, VORONINA EH.V, GEJN V.L
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to new 5-aryl-1-phenyl-4-heteroyl-3-hydroxy-3-pyrroline-2-ones of the formula: ^ wherein (1) X means sulfur atom (S); R means (CH3)2CH; (2) X means sulfur atom (S); R means (CH3)3C; (3) X means oxygen atom (O); R means (CH3)3C. Compounds of the formula (I) are prepared by interaction of the corresponding heteroylpyruvic acid methyl ester with mixture of aniline and aromatic aldehyde in acetic acid medium at short-time heating. Compounds elicit an anti-bacterial activity with value MIC = 3.9-7.8 mcg/ml as compared with 62-1000 mcg/ml for analogue. ^ EFFECT: valuable properties of compounds. ^ 1 tbl, 3 ex