LOW HYGROSCOPICITY ARYPYPRAZOLE MEDICINAL AGENT AND METHODS FOR ITS PREPARING

FIELD: medicine, pharmacology. ^ SUBSTANCE: invention relates to arypyprazole anhydrous crystals B showing characteristic peaks in powdered roentgen rays diffraction at 2theta = 11.0°, 16.6°, 19.3°, 20.3° and 22.1°, specific infrared absorption bands at 2945, 2812, 1678, 1627, 1448, 1377, 1173, 960...

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Bibliographische Detailangaben
Hauptverfasser:	SINKHAMA KOITI, TOMINAGA MITIAKI, FUDZIMOTO KIJOSI, JABUUTI TSUJOSI, JAMADA SOKHEI, TANIGUTI JOUITI, NAKAGAVA TOMONORI, TAKAKHASI MASANORI, OI JOSIKHIRO, ISIGAMI MAKOTO, NISIOKA JOSIKHIRO, ABE KAORU, KOBAJASI NORIJUKI, BANDO TAKUDZI, KAVASAKI DZUNITI, TOMIKAVA KENDZI, FUDZIMURA TSUTOMU, AOKI SATOSI, UTSUMI NAOTO
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine, pharmacology. ^ SUBSTANCE: invention relates to arypyprazole anhydrous crystals B showing characteristic peaks in powdered roentgen rays diffraction at 2theta = 11.0°, 16.6°, 19.3°, 20.3° and 22.1°, specific infrared absorption bands at 2945, 2812, 1678, 1627, 1448, 1377, 1173, 960 and 779 cm-1 in IR-spectrum, endothermic peak at 141.5° in thermogravimetric/differential thermic analysis and endothermic peak at 140.7° C in differential scanning calorimetry, arypyprazole A hydrate, to methods for their preparing, pharmaceutical compositions comprising arypyprazole crystals B and methods for their preparing. Invention provides reduced hygroscopicity of arypyprazole crystals B. ^ EFFECT: improved preparing method. ^ 57 cl, 14 tbl, 24 ex