METHOD FOR PREPARING AZITHROMYCIN

METHOD FOR PREPARING AZITHROMYCIN

FIELD: antibiotics, chemical technology. ^ SUBSTANCE: azithromycin is prepared by the methylation reaction of 11-aza-10-deoxo-10-dihydroerythromycin in boiling in chlorinated hydrocarbon medium, in the presence of formic acid taken in the amount from 0.1 to 0.2 weight part per one weight part of 11-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KUZ'MIN I.A, PSHENICHNIKOV V.G, RABINOVICH I.M
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:FIELD: antibiotics, chemical technology. ^ SUBSTANCE: azithromycin is prepared by the methylation reaction of 11-aza-10-deoxo-10-dihydroerythromycin in boiling in chlorinated hydrocarbon medium, in the presence of formic acid taken in the amount from 0.1 to 0.2 weight part per one weight part of 11-aza-10-deoxo-10-dihydroerythromycin. Paraform is used as a methylating agent taken in the amount from 0.05 to 0.2 weight part per one part of 11-aza-10-deoxo-10-dihydroerythromycin. Invention provides increasing yield and improved quality of the end product. ^ EFFECT: improved preparing method. ^ 2 cl, 3 ex