DIAZEPANE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND INHIBITOR OF BLOOD COAGULATION ACTIVATED FACTOR X

FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention describes diazepane derivative of the general formula (I) ^ or its pharmaceutically acceptable salt wherein ring B means phenyl; ring A means pyridyl substituted with halogen atom optionally, or phenyl substituted optionally with l...

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Bibliographische Detailangaben
Hauptverfasser:	KHIRAJAMA FUKUSI, SUGASAVA KEIZO, KAVAZOE SOUITIROU, ISIKHARA TSUKASA, MATSUMOTO JUZO, KOSIO KHIROJUKI, SEKI NORIO, SIGENAGA TAKESI, KHATIJA SUNITIRO, SIRAKI RIOTA, KOGA JUDZI
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention describes diazepane derivative of the general formula (I) ^ or its pharmaceutically acceptable salt wherein ring B means phenyl; ring A means pyridyl substituted with halogen atom optionally, or phenyl substituted optionally with lower alkyl, lower alkoxy-group or halogen atom; X1 represents -C(=O)-NR2- or -NR2-C(=O)- wherein R2 means hydrogen atom; X2 represents -C(=O)-NR3- or NR3-C(=O)- wherein R3 means hydrogen atom; R represents hydrogen atom or halogen atom; R1 means lower alkyl. Also, invention relates to a pharmaceutical composition and inhibitor of blood coagulation activated factor X that can be used for prophylaxis and treatment of patients suffering with thrombosis or embolism. ^ EFFECT: valuable medicinal properties of compound. ^ 5 cl, 5 tbl, 6 ex