METHOD FOR PREPARING 2,4-DIALKYLINDOLO[2,3-H]-1-OXAAZULENIUM CHLORIDES

METHOD FOR PREPARING 2,4-DIALKYLINDOLO[2,3-H]-1-OXAAZULENIUM CHLORIDES

FIELD: organic chemistry, chemical technology, medicine. ^ SUBSTANCE: invention relates to a method for preparing new 2,4-dialkylindolo[2,3-h]-1-oxaazulenium chlorides of the general formula (I): ^ wherein Ia: R is -OCH3; R1 is CH3; Ib: R is hydrogen atom (H); R1 is CH3; Ic: R is -O-CH2-O-; R1 is CH...

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Bibliographische Detailangaben
Hauptverfasser: SMIRNOV S.K, STROGANOVA T.A, BUTIN A.V
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:FIELD: organic chemistry, chemical technology, medicine. ^ SUBSTANCE: invention relates to a method for preparing new 2,4-dialkylindolo[2,3-h]-1-oxaazulenium chlorides of the general formula (I): ^ wherein Ia: R is -OCH3; R1 is CH3; Ib: R is hydrogen atom (H); R1 is CH3; Ic: R is -O-CH2-O-; R1 is CH3; Id: R is -O-CH2-CH2-O-; R1 is CH3; Ie: R is -OCH3; R1 is C2H5; If: -O-CH2-O-; R1 is C2H5. Method involves passing gaseous hydrogen chloride through solution of the corresponding 2-acetylaminoarylbis-(5-alkylfur-2-yl)methane of the formula (II): ^ in methanol at boiling for 80-90 min. Method provides preparing new tetracyclic derivatives eliciting the potential anticancer activity. ^ EFFECT: improved preparing method, valuable medicinal properties of compounds. ^ 2 tbl, 5 ex