(DL)-1-HYDROXY-3,7,7,9,9-PENTAMETHYL-1,4,8-TRIAZASPIRO[4,5]DECANE-2-ONE AND METHOD FOR ITS PREPARING
FIELD: organic chemistry, chemical technology, medicine. ^ SUBSTANCE: invention relates to (DL)-1-hydroxy-3,7,7,9,9-pentamethyl-1,4,8-triazaspiro[4,5]decane-2-one of the formula (1) . ^ Also, invention describes a method for preparing this compound by treatment of DL-alanine hydroxamic acid with ket...
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Zusammenfassung: | FIELD: organic chemistry, chemical technology, medicine. ^ SUBSTANCE: invention relates to (DL)-1-hydroxy-3,7,7,9,9-pentamethyl-1,4,8-triazaspiro[4,5]decane-2-one of the formula (1) . ^ Also, invention describes a method for preparing this compound by treatment of DL-alanine hydroxamic acid with ketone wherein aminoketone - 2,2,6,6-tetramethylpiperidine-4-one is used as ketone, and process is carried out in benzene medium in the mole ratio of reagents: alpha-aminohydroxamic acid : aminoketone = 1:1.1 followed by isolation of the end product. Invention provides preparing new compound that can be used as a nontoxic antimetastatic medicinal agent. ^ EFFECT: improved preparing method, valuable medicinal properties of compound. ^ 3 cl, 1 ex |
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