GLUCOKINASE ACTIVATING AGENTS

FIELD: organic chemistry, biochemistry, medicine, endocrinology. ^ SUBSTANCE: invention relates to compounds representing amide of the formula (I): ^ wherein * means asymmetric carbon atom; R1 and R2 mean independently of one another hydrogen or halogen atom, amino-, hydroxyamino-, nitro-, cyano-, sulfonamido-group, (lower)-alkyl, -OR5, -C(O)OR5, perfluoro-(lower)-alkyl, (lower)-alkylthio-, perfluoro-(lower)-alkylthio-, (lower)-alkylsulfonyl-, perfluoro-(lower)-alkylsulfonyl-, or (lower)-alkylsulfinyl-group; R3 means cycloalkyl comprising from 3 to 7 carbon atoms, or (lower)-alkyl comprising from 2 to 4 carbon atoms; R4 means (O)NHR40 or unsubstituted or monosubstituted five- or six-membered heteroaromatic ring bound by ring carbon atom with given amino-group wherein this five- or six-membered heteroaromatic ring comprises from 1 to 3 heteroatoms taken among sulfur, oxygen and nitrogen atoms and wherein one heteroatom represents nitrogen atom that is adjacent with connecting ring carbon atom; this monosubstituted heteroaromatic ring is monosubstituted by ring carbon atom that differs from adjacent atom with connecting carbon atom and substitute is taken among the following row including (lower)-alkyl, halogen atom, nitro-group, cyano-group, -(CH2)n-OR6, -(CH2)n-C(O)OR7, -(CH2)n-C(O)NHR6, -C(O)-C(O)OR8 and -(CH2)n-NHR6, or its pharmaceutically acceptable salts. These compounds are activators of glucokinase that enhance secretion of insulin in treatment of diabetes mellitus of type II. ^ EFFECT: valuable medicinal properties of compounds. ^ 32 cl, 175 ex