PHARMACEUTICAL COMPOSITION, METHODS FOR ITS PREPARING, STABLE WATER-INSOLUBLE COMPLEXES, METHOD FOR CONVERSION OF THERAPEUTICALLY ACTIVE COMPOUND AND THERAPEUTICALLY ACTIVE COMPOUND

FIELD: pharmaceutical technology and compositions, pharmacy. ^ SUBSTANCE: invention relates to pharmaceutical compositions comprising stable water-insoluble complex consisting of the stable amorphous therapeutically active compound dispersed in water-insoluble ionic polymer at the molecular level. U...

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Hauptverfasser:	ALBEJNO ANTOUNIO A, SHAKH NAVNIT KHARGOVINDAS, FUAPRADIT VANTANI, SANDKHU KHARPRIT K
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	FIELD: pharmaceutical technology and compositions, pharmacy. ^ SUBSTANCE: invention relates to pharmaceutical compositions comprising stable water-insoluble complex consisting of the stable amorphous therapeutically active compound dispersed in water-insoluble ionic polymer at the molecular level. Useful insoluble ionic polymers have molecular mass above about 80 000 Da and vitrification point about 50oC or above. Compounds are subjected for microprecipitation in amorphous form on ionic polymers. Proposed complexes enhance biological availability of slightly soluble therapeutically active compounds significantly. ^ EFFECT: improved preparing method, enhanced and valuable properties of composition. ^ 41 cl, 7 dwg, 2 tbl, 16 ex