FLUORINATED DERIVATIVES OF 2-AROYL-3-METHYL-6,7-DIFLUOROBENZ[4,5]-IMIDAZO[1,2-B][1,3]-THIAZOLES AS INHIBITORS OF MEASLES VIRUS REPRODUCTION

FLUORINATED DERIVATIVES OF 2-AROYL-3-METHYL-6,7-DIFLUOROBENZ[4,5]-IMIDAZO[1,2-B][1,3]-THIAZOLES AS INHIBITORS OF MEASLES VIRUS REPRODUCTION

FIELD: organic chemistry, molecular biology, virology, medicine. ^ SUBSTANCE: invention relates to the compound 2-aroyl-3-methyl-6,7-difluorobenz[4,5]-imidazo[2,1-b][1,3]-thiazoles of the general formula (1a-o): ^ wherein R means hydrogen, bromine, chlorine atom, hydroxy-group, group -NHCOCH3, group...

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Hauptverfasser: POKROVSKIJ A.G, ROMANOVA S.A, KOTOVSKAJA S.K, CHUPAKHIN O.N, IL'ICHEVA T.N, CHARUSHIN V.N
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Sprache:eng ; rus
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator POKROVSKIJ A.G
ROMANOVA S.A
KOTOVSKAJA S.K
CHUPAKHIN O.N
IL'ICHEVA T.N
CHARUSHIN V.N
description FIELD: organic chemistry, molecular biology, virology, medicine. ^ SUBSTANCE: invention relates to the compound 2-aroyl-3-methyl-6,7-difluorobenz[4,5]-imidazo[2,1-b][1,3]-thiazoles of the general formula (1a-o): ^ wherein R means hydrogen, bromine, chlorine atom, hydroxy-group, group -NHCOCH3, group -OCOCH3, nitro-group, methyl, methoxy-group or phenyl that effective inhibitors of measles virus. Compounds of formulas (1a) and (1b) given in the description elicit ability to inhibit reproduction of measles virus in transplantable cultured cells Vero of green monkey kidney. Antiviral activity of compound (1a) with respect to measles virus exceeds activity of ribavirin significantly. ^ EFFECT: expanded assortment of agents of indicated designation, valuable antiviral properties of compound. ^ 1 tbl, 2 dwg, 6 ex
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title FLUORINATED DERIVATIVES OF 2-AROYL-3-METHYL-6,7-DIFLUOROBENZ[4,5]-IMIDAZO[1,2-B][1,3]-THIAZOLES AS INHIBITORS OF MEASLES VIRUS REPRODUCTION
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