NUCLEIC ACID MOLECULE ENCODING LIGAND TIE-2, LIGAND TIE-2 AND METHOD FOR ITS PREPARING, VECTOR, STRAIN OF CELLS COS, ANTIBODY, CONJUGATE OF LIGAND TIE-2, LIGAND BODY, PHARMACEUTICAL COMPOSITION, METHOD FOR PROPHYLAXIS OR ATTENUATION OF NEOVASCULARIZATION AND METHOD FOR IDENTIFICATION OF TIE-2 RECEPTOR ANTAGONIST

FIELD: genetic engineering, molecular biology, biochemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to genes encoding tyrosine kinases and can be used for diagnosis. Human ligand TIE-2 represents TIE-2 receptor antagonist. Ligand TIE-2 is prepared using vector pBluescript KS that comprises nucleic acid encoding ligand TIE-2. Conjugate is prepared by coupling ligand TIE-2 with cytotoxic agent. Ligand body represents ligand TIE-2 fused with immunoglobulin contact site. Pharmaceutical composition contains effective amount of ligand TIE-2 or ligand body and it is used in method for prophylaxis or attenuation of neovascularization. Invention provides diagnosis and treatment of diseases associated with endothelial cells comprising TIE-2 receptors. Invention provides the development of diagnostic systems for identification of TIE-2 receptor antagonist. ^ EFFECT: improved prophylaxis and treatment method, valuable medicinal properties of ligand. ^ 16 cl, 14 dwg, 12 ex