DERIVATIVES OF CAPUROMYCIN, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS FOR TREATMENT OR PROPHYLAXIS OF BACTERIAL INFECTION

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of capuromycin of the formula (I) wherein R1 represents hydrogen atom, aryl group, heterocyclic group, alkyl group, alkenyl group and similar to that are optionally substituted; R2 represents hydrogen atom or alkyl group; R3 represents hydrogen atom or hydroxyl group; X1 and X2 represent oxygen or nitrogen atom that can be substituted, and to pharmaceutically acceptable derivatives or salts. Compounds show an antibacterial activity, among them, against to Mycobacterium tuberculosis. Except for, the invention relates to pharmaceutical compositions eliciting an antibacterial activity and agents used for prophylaxis or treatment of bacterial infections comprising the above described compound and to methods for prophylaxis or treatment of bacterial infections in warm- -blooded animals involving administration the effective dose of the above described compound. EFFECT: valuable medicinal properties of compound and composition. 51 cl, 11 tbl, 120 ex