METHOD FOR DETERMINING IN VIVO MICROSOME OXIDATION SYSTEM STATE

METHOD FOR DETERMINING IN VIVO MICROSOME OXIDATION SYSTEM STATE

FIELD: medicine. SUBSTANCE: method involves per os administering standard dose of pharmaprobe subjected to metabolism on mainly epoxydiol and hydroxyl way with following unchanged preparation concentrations being determined in dynamics. Dynamic and concentration data are processed by applying statis...

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Hauptverfasser: REMBOVSKIJ V.R, ANTONOVA O.M, GORBUNOVA L.V, POPOVICH V.I, FOMENKO N.A
Format: Patent
Sprache:eng ; rus
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator REMBOVSKIJ V.R
ANTONOVA O.M
GORBUNOVA L.V
POPOVICH V.I
FOMENKO N.A
description FIELD: medicine. SUBSTANCE: method involves per os administering standard dose of pharmaprobe subjected to metabolism on mainly epoxydiol and hydroxyl way with following unchanged preparation concentrations being determined in dynamics. Dynamic and concentration data are processed by applying statistical moments method and plots are built in coordinate system AUC/D on D. Microsome oxidation system state violating norm is determined from the fact that dependency of AUC/D on D including other computed pharmacokinetic parameters is deviated beyond ±2delta limits when compared to preset reference values. EFFECT: high accuracy and sensitivity in determining oxidation metabolism phenotype; high accuracy of intoxication and professional diseases diagnosis. 7 dwg, 7 tbl
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title METHOD FOR DETERMINING IN VIVO MICROSOME OXIDATION SYSTEM STATE
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