METHOD FOR DETERMINING IN VIVO MICROSOME OXIDATION SYSTEM STATE

FIELD: medicine. SUBSTANCE: method involves per os administering standard dose of pharmaprobe subjected to metabolism on mainly epoxydiol and hydroxyl way with following unchanged preparation concentrations being determined in dynamics. Dynamic and concentration data are processed by applying statis...

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Bibliographische Detailangaben
Hauptverfasser:	REMBOVSKIJ V.R, ANTONOVA O.M, GORBUNOVA L.V, POPOVICH V.I, FOMENKO N.A
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	FIELD: medicine. SUBSTANCE: method involves per os administering standard dose of pharmaprobe subjected to metabolism on mainly epoxydiol and hydroxyl way with following unchanged preparation concentrations being determined in dynamics. Dynamic and concentration data are processed by applying statistical moments method and plots are built in coordinate system AUC/D on D. Microsome oxidation system state violating norm is determined from the fact that dependency of AUC/D on D including other computed pharmacokinetic parameters is deviated beyond ±2delta limits when compared to preset reference values. EFFECT: high accuracy and sensitivity in determining oxidation metabolism phenotype; high accuracy of intoxication and professional diseases diagnosis. 7 dwg, 7 tbl