NEW BICYCLONUCLEOSIDE ANALOGS

FIELD: organic chemistry, biochemistry, nucleic acids. SUBSTANCE: invention relates to bicyclonucleoside analogs of the general formula (1) and oligonucleotides based on thereof comprising one or some structural units of the general formula (1a) wherein R1 represents hydrogen atom, protecting group,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	IMANISI TAKESI, KOKHIGA SATOSI
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, biochemistry, nucleic acids. SUBSTANCE: invention relates to bicyclonucleoside analogs of the general formula (1) and oligonucleotides based on thereof comprising one or some structural units of the general formula (1a) wherein R1 represents hydrogen atom, protecting group, phosphoric acid group and others; R2 represents azido-group or amino-group that can be substituted; B represents purine-9-yl or 2-oxo-1,2-dihydropyrimidine- 1-yl group that can be substituted with one or some substituents. Oligonucleotides can be used as anti-sense or antigenic agents. EFFECT: valuable biological and biochemical properties of compounds. 15 cl, 1 dwg, 3 tbl