DERIVATIVES OF PIPERAZINE, PHARMACEUTICAL COMPOSITION ELICITING INHIBITORY ACTIVITY WITH REGARDS TO XA FACTOR
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes derivatives of piperazine of the general formula (I): wherein A represents optionally substituted 5- or 6-membered monocyclic aromatic ring with 1, 2 or 3 nitrogen atoms; B1, B2, B3, B4 represent independently CH or nitroge...
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| creator | UORNER PITER DZHEJMS RODZHERS NOVAK TORSTEN |
| description | FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes derivatives of piperazine of the general formula (I): wherein A represents optionally substituted 5- or 6-membered monocyclic aromatic ring with 1, 2 or 3 nitrogen atoms; B1, B2, B3, B4 represent independently CH or nitrogen atom under condition that at least one among B1, B2, B3, B4 is nitrogen atom; X1 represents CO; T1 represents N; T2 represents N; L1 represents (1-4C)-alkylene; R2 and R3 form in common C1-4-alkylene group so that group -T1(R2)-L1-T2(R3)- forms piperazine ring; X2 represents S(O)2; Q represents phenyl, naphthyl, phenyl-(2-4C)-alkenyl, benzofuranyl, indolyl and Q is substituted with one substituent taken among halogen atoms, phenyl substituted with halogen atom. Invention describes also pharmaceutical composition eliciting inhibitory activity with regards to Xa factor. Invention provides preparing derivatives of piperazine eliciting anti-thrombolytic and anti-coagulating properties. EFFECT: valuable medicinal properties of compounds. 4 cl, 1 tbl, 7 ex |
| format | Patent |
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SUBSTANCE: invention describes derivatives of piperazine of the general formula (I): wherein A represents optionally substituted 5- or 6-membered monocyclic aromatic ring with 1, 2 or 3 nitrogen atoms; B1, B2, B3, B4 represent independently CH or nitrogen atom under condition that at least one among B1, B2, B3, B4 is nitrogen atom; X1 represents CO; T1 represents N; T2 represents N; L1 represents (1-4C)-alkylene; R2 and R3 form in common C1-4-alkylene group so that group -T1(R2)-L1-T2(R3)- forms piperazine ring; X2 represents S(O)2; Q represents phenyl, naphthyl, phenyl-(2-4C)-alkenyl, benzofuranyl, indolyl and Q is substituted with one substituent taken among halogen atoms, phenyl substituted with halogen atom. Invention describes also pharmaceutical composition eliciting inhibitory activity with regards to Xa factor. Invention provides preparing derivatives of piperazine eliciting anti-thrombolytic and anti-coagulating properties. EFFECT: valuable medicinal properties of compounds. 4 cl, 1 tbl, 7 ex</description><edition>7</edition><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040310&DB=EPODOC&CC=RU&NR=2225404C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040310&DB=EPODOC&CC=RU&NR=2225404C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>UORNER PITER</creatorcontrib><creatorcontrib>DZHEJMS RODZHERS</creatorcontrib><creatorcontrib>NOVAK TORSTEN</creatorcontrib><title>DERIVATIVES OF PIPERAZINE, PHARMACEUTICAL COMPOSITION ELICITING INHIBITORY ACTIVITY WITH REGARDS TO XA FACTOR</title><description>FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes derivatives of piperazine of the general formula (I): wherein A represents optionally substituted 5- or 6-membered monocyclic aromatic ring with 1, 2 or 3 nitrogen atoms; B1, B2, B3, B4 represent independently CH or nitrogen atom under condition that at least one among B1, B2, B3, B4 is nitrogen atom; X1 represents CO; T1 represents N; T2 represents N; L1 represents (1-4C)-alkylene; R2 and R3 form in common C1-4-alkylene group so that group -T1(R2)-L1-T2(R3)- forms piperazine ring; X2 represents S(O)2; Q represents phenyl, naphthyl, phenyl-(2-4C)-alkenyl, benzofuranyl, indolyl and Q is substituted with one substituent taken among halogen atoms, phenyl substituted with halogen atom. Invention describes also pharmaceutical composition eliciting inhibitory activity with regards to Xa factor. Invention provides preparing derivatives of piperazine eliciting anti-thrombolytic and anti-coagulating properties. 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SUBSTANCE: invention describes derivatives of piperazine of the general formula (I): wherein A represents optionally substituted 5- or 6-membered monocyclic aromatic ring with 1, 2 or 3 nitrogen atoms; B1, B2, B3, B4 represent independently CH or nitrogen atom under condition that at least one among B1, B2, B3, B4 is nitrogen atom; X1 represents CO; T1 represents N; T2 represents N; L1 represents (1-4C)-alkylene; R2 and R3 form in common C1-4-alkylene group so that group -T1(R2)-L1-T2(R3)- forms piperazine ring; X2 represents S(O)2; Q represents phenyl, naphthyl, phenyl-(2-4C)-alkenyl, benzofuranyl, indolyl and Q is substituted with one substituent taken among halogen atoms, phenyl substituted with halogen atom. Invention describes also pharmaceutical composition eliciting inhibitory activity with regards to Xa factor. Invention provides preparing derivatives of piperazine eliciting anti-thrombolytic and anti-coagulating properties. EFFECT: valuable medicinal properties of compounds. 4 cl, 1 tbl, 7 ex</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVATIVES OF PIPERAZINE, PHARMACEUTICAL COMPOSITION ELICITING INHIBITORY ACTIVITY WITH REGARDS TO XA FACTOR |
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