DERIVATIVES OF PIPERAZINE, PHARMACEUTICAL COMPOSITION ELICITING INHIBITORY ACTIVITY WITH REGARDS TO XA FACTOR

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes derivatives of piperazine of the general formula (I): wherein A represents optionally substituted 5- or 6-membered monocyclic aromatic ring with 1, 2 or 3 nitrogen atoms; B1, B2, B3, B4 represent independently CH or nitrogen atom under condition that at least one among B1, B2, B3, B4 is nitrogen atom; X1 represents CO; T1 represents N; T2 represents N; L1 represents (1-4C)-alkylene; R2 and R3 form in common C1-4-alkylene group so that group -T1(R2)-L1-T2(R3)- forms piperazine ring; X2 represents S(O)2; Q represents phenyl, naphthyl, phenyl-(2-4C)-alkenyl, benzofuranyl, indolyl and Q is substituted with one substituent taken among halogen atoms, phenyl substituted with halogen atom. Invention describes also pharmaceutical composition eliciting inhibitory activity with regards to Xa factor. Invention provides preparing derivatives of piperazine eliciting anti-thrombolytic and anti-coagulating properties. EFFECT: valuable medicinal properties of compounds. 4 cl, 1 tbl, 7 ex