DERIVATIVES OF INDOLE, MEDICINAL AGENT CONTAINING THEREOF, METHOD FOR THEIR PREPARING (VARIANTS)

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to inhibitors of tyrosine kinases of type of bis-indolyl-containing compounds of the formula (I): wherein Z means group of the general formula (II): wherein A, B, X, Z, R1-R10 have values indicated in the invention claim...

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Bibliographische Detailangaben
Hauptverfasser:	BEMER FRANK-D, PONGRATS GERVIG, KUR SABINA, TELLER STEFFEN, KHUFSKI KHARAL'D, BEKERS TOMAS, POPP AL'FRED, MABOBI ZIAVOSH, JUKER ANDREA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to inhibitors of tyrosine kinases of type of bis-indolyl-containing compounds of the formula (I): wherein Z means group of the general formula (II): wherein A, B, X, Z, R1-R10 have values indicated in the invention claim and also to method for their preparing and medicinal agent based on these compounds. Invention provides preparing new inhibitors. EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds. 10 cl, 2 tbl, 194 ex