NEW DERIVATIVES OF AMINOCYCLOHEXANE

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new compounds of the formula (I): wherein U means oxygen atom or unshared one-pair electrons; V means oxygen, sulfur atom, -CH2-, -CH=CH- or ; W means CO, COO, CONR1, CSO, CSNR1, SO2 or SO2NR1; m and n each means independently of one another a number from 0 to 7, and sum m + n is from 0 to 7 under condition that m doesn't mean 0 if V means oxygen or sulfur atom; A1 means hydrogen atom, lower alkyl, hydroxy(lower)alkyl or (lower)alkenyl; A2 means (lower)alkyl, cycloalkyl, cycloalkyl(lower)alkyl or (lower)alkenyl optionally substituted with the group R2; A3 and A4 each means hydrogen atom or (lower)alkyl; A5 means hydrogen atom, (lower)alkyl, (lower)alkenyl or aryl(lower)alkyl; A6 means (lower)alkyl, cycloalkyl, aryl, aryl(lower)alkyl, heteroaryl, heteroaryl(lower)alkyl, (lower)alkoxycarbonyl(lower)alkyl; R2 means hydroxy-group, hydroxy(lower)alkyl, (lower)alkoxy-group, (lower)alkoxycarbonyl, N(R4,R5) or thio(lower)alkoxy- -group; R1, R3, R4, R5 each means independently of one another hydrogen atom or (lower)alkyl; and to their pharmaceutically acceptable salts and/or pharmaceutically acceptable esters. These compounds can be used in treatment and/or prophylaxis of diseases associated with 2,3-oxidosqualenlanosterol cyclase, such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycosis and parasitic infections. EFFECT: valuable medicinal and biochemical properties of compounds. 35 cl, 1 tbl, 55 ex