GENE-THERAPEUTIC METHODS FOR ADMINISTRATION OF APOLIPOPROTEIN A-1 AGONISTS AND THEIR USING IN TREATMENT OF DYSLIPIDEMIC DISORDERS

FIELD: molecular biology, genetic therapy, medicine, amino acids. SUBSTANCE: invention relates to nucleotide sequence encoding agonist of ApoA-1 comprising the following components: (i) 15-29 amino acid peptide that forms amphipathic alpha-helix in the presence of lipids and showing structural formula (I): or its pharmaceutically acceptable salt wherein X1 represents Pro (P), Ala (A), Gly (G), Gln (Q), Asn (N) or Asp (D); X2 represents aliphatic residue; X3 represents Leu (L) or Phe (F); X4 represents acid residue; X5 represents Leu (L) or Phe (F); X6 represents Leu (L) or Phe (F); X7 represents hydrophilic residue; X8 represents acid or basic residue; X9 represents Leu (L) or Gly (G); X10 represents Leu (L), Trp (W) or Gly (G); X11 represents hydrophilic residue; X12 represents hydrophobic residue;X13 represents Gly (G) or aliphatic residue; X14 represents Leu (L), Trp (W) or Gly (G); X15 represents hydrophilic residue; X16 represents hydrophobic residue; X17 represents hydrophobic residue; X18 represents Gln (Q), Asn (N) or basic residue; X19 represents Gln (Q), Asn (N) or basic residue; X20 represents basic residue; X21 represents aliphatic residue; X22 represents basic residue; X23 is absent or represents basic residue; or (ii) deleted form of structural formula (I) wherein 1-8 residues among are deleted; or (iii) alternated form of structural formula (I) wherein at least one residue among is substituted for another residue by conservative mechanism. Compounds are useful for treatment of diseases associated with dyslipidemia. Invention describes also methods for preparing peptide encoded by these nucleotide sequences, pharmaceutical compositions containing thereof and methods for treatment of diseases associated with dyslipidemia. EFFECT: valuable medicinal properties of peptides, enhanced effectiveness of disease treatment. 68 cl, 10 tbl, 5 dwg, 6 ex