METHOD FOR PREPARING CATALYTIC ANTIBODIES (VARIANTS), ANTIGENS FOR IMMUNIZATION AND NUCLEOTIDE SEQUENCE

FIELD: biotechnology, proteins. SUBSTANCE: invention relates to preparing potential medicinal agents directed to destruction of protein antigens, in particular, glycoprotein gp-120 as the main surface protein of human immunodeficiency virus. Catalytic antibodies are prepared using animals with spont...

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Bibliographische Detailangaben
Hauptverfasser:	ALEKSANDROVA E.S, PONOMARENKO N.A, VOROB'EV I.I, DEMIN A.V, KOLESNIKOV A.V, GABIBOV A.G
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology, proteins. SUBSTANCE: invention relates to preparing potential medicinal agents directed to destruction of protein antigens, in particular, glycoprotein gp-120 as the main surface protein of human immunodeficiency virus. Catalytic antibodies are prepared using animals with spontaneous and induced autoimmune pathologies by administration to them a fused protein consisting of the myelin basic protein (its fragments) and potential substrate of catalytic antibody (its fragment) or phosphate derivative of peptide with the following amino acid sequence: Leu-Ala-Glu-Glu-Glu-Val. EFFECT: improved preparing method, valuable biological and immune properties. 9 cl, 16 dwg, 5 ex