THROMBIN INHIBITORS

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) wherein radical values are determined in the invention claim and their pharmaceutically acceptable salts. Compounds are inhibitors of thrombin and can be used for modulation of thrombin fun...

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Hauptverfasser: LI SANG KOO, PARK KHEE DONG, DZUNG VON KHIUK, LI SUN KHVA, PARK CHEOL VON, LI KOO
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creator LI SANG KOO
PARK KHEE DONG
DZUNG VON KHIUK
LI SUN KHVA
PARK CHEOL VON
LI KOO
description FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) wherein radical values are determined in the invention claim and their pharmaceutically acceptable salts. Compounds are inhibitors of thrombin and can be used for modulation of thrombin function and as anticoagulating agents. Compounds show high biological availability also. EFFECT: valuable biological properties of inhibitors. 9 cl, 2 tbl, 47 ex
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title THROMBIN INHIBITORS
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