THROMBIN INHIBITORS

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) wherein radical values are determined in the invention claim and their pharmaceutically acceptable salts. Compounds are inhibitors of thrombin and can be used for modulation of thrombin fun...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LI SANG KOO, PARK KHEE DONG, DZUNG VON KHIUK, LI SUN KHVA, PARK CHEOL VON, LI KOO
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) wherein radical values are determined in the invention claim and their pharmaceutically acceptable salts. Compounds are inhibitors of thrombin and can be used for modulation of thrombin function and as anticoagulating agents. Compounds show high biological availability also. EFFECT: valuable biological properties of inhibitors. 9 cl, 2 tbl, 47 ex