N-ALKANOYLPHENYLALANINE DERIVATIVES

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to N-alkanoylphenylalanine derivatives of the formula (I) wherein values of radical X, X', Y and Z are given in the invention claim and to their pharmaceutically acceptable salts and esters. Proposed compounds show high antagonist...

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Bibliographische Detailangaben
Hauptverfasser:	TILLI DZHEFFERSON RAJT, GATRI ROBERT UILL'JAM, KHUAN TAJNAN, CHEN' LI, SIDDURI AKITARAO, KHALL KENNET G
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to N-alkanoylphenylalanine derivatives of the formula (I) wherein values of radical X, X', Y and Z are given in the invention claim and to their pharmaceutically acceptable salts and esters. Proposed compounds show high antagonistic activity with respect to VLA-4 and can be used for treatment of rheumatic arthritis, disseminated sclerosis, asthma and intestine inflammatory disease. EFFECT: valuable medicinal properties of compounds. 50 cl, 16 tbl, 182 ex