DERIVATIVES OF 1,5-DIHYDROPYRAZOLO[3,4-D]- PYRIMIDINONE

FIELD: organic chemistry. SUBSTANCE: invention relates to new derivatives of 1,5-dihydropyrazolo[3,4-d]- pyrimidinone of the general formula (I) eliciting property of inhibitor of phosphodiesterases that can be used, for example, in hypertension, angina and cardiac diseases. In compound of the formula (I) A and D mean in common residue of the formula N= CH-R2 or -NH-HC=O wherein R2 means hydrogen atom, linear alkoxyl with number of carbon atom below 4, linear alkyl with number of carbon atoms below 4 optionally substituted with hydroxyl; R1 means linear acyl with number of carbon atoms below 6, linear alkyl with number of carbon atoms below 10 possibly substituted with hydroxyl; E means linear alkylene chain with number of carbon atoms below 6 and possibly substituted with hydroxyl; V means phenyl; L means phenyl optionally substituted up to three times with similarly or differently linear alkyl, alkoxyl, alkoxycarbonyl with number of carbon atoms below 6 or group of the formula -(W)a-NR7R8, wherein a = 0 or 1; W means residue of the formula -SO2, R7 and R8 mean hydrogen atom; or L means phenyl that can be substituted with phenyl that in turn can be substituted similarly or differently up to two times with halogen atom, linear alkyl or alkoxyl with number of carbon atoms below 5, respectively; or 5- 6-membered nitrogen- containing heterocycle; or -(W')b-NR9R10, wherein b has values of a; R9 and R10 both mean hydrogen atom or with nitrogen atom form in common 6-membered heterocycle that can comprise optionally additionally oxygen atom or residue NR6 wherein R6 means hydrogen atom or linear or branched alkyl with number of carbon atoms below 4; W' has value W, or L means residue of the formula (2) , or V means alkyl; T means residue of the formula -CH2-X-Y wherein X means a bond; Y means alkylene chain with number of carbon atoms below 9, and their tautomers and salts. EFFECT: new compounds described above. 4 cl, 3 sch, 2 tbl, 116 ex