METHOD FOR PREPARING QUINOLINE CARBALDEHYDE

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde of the formula (I) that involves oxidation of 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline with hypohalogenic acid salt in the pr...

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Hauptverfasser: MATSUMOTO KHIROO, TAKADA JASUTAKA, SIMISU TAKANORI
Format: Patent
Sprache:eng
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Zusammenfassung:FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde of the formula (I) that involves oxidation of 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline with hypohalogenic acid salt in the presence of quaternary ammonium salt. 2-Cyclopropyl-4-(4-fluorophenyl)- quinoline-3-carbaldehyde can be used as an intermediate compound in synthesis of inhibitor of HNG-CoA- reductase using as medicinal agent for reduction of cholesterol level. Invention provides the development of simple and industrially favorable method for preparing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3- carbaldehyde with high yield. EFFECT: improved preparing method. 2 cl, 2 ex