METHOD FOR PREPARING VACCINE AGAINST TUBERCULOSIS

METHOD FOR PREPARING VACCINE AGAINST TUBERCULOSIS

FIELD: veterinary microbiology, phthisiology. SUBSTANCE: invention relates to preparing dead cell-free (molecular) vaccine of new type. Method involves culturing mycobacteria from the strain BCG, isolation of two fractions cytoplasmic and fraction of cellular envelopes. Fraction of cellular envelope...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHAMOV V.V, BAZHIN M.A, OSHCHEPKOV V.G, OKOLELOV V.I, NEVOROTOVA G.P
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:FIELD: veterinary microbiology, phthisiology. SUBSTANCE: invention relates to preparing dead cell-free (molecular) vaccine of new type. Method involves culturing mycobacteria from the strain BCG, isolation of two fractions cytoplasmic and fraction of cellular envelopes. Fraction of cellular envelopes is conjugated on cellulose matrix in the ratio = 1:10 (by mass) in the presence of chrome trichloride, then cytoplasmic fraction is added up to the protein content 1.5-2 mg/ml. Method provides preparing ecologically pure vaccine eliciting high immunogenicity. EFFECT: improved preparing method. 3 tbl, 4 ex