METHOD FOR PREPARING PHARMACEUTICAL PRODUCT CARVEDILOL AND INTERMEDIATE COMPOUND

METHOD FOR PREPARING PHARMACEUTICAL PRODUCT CARVEDILOL AND INTERMEDIATE COMPOUND

FIELD: chemical technology, pharmacy. SUBSTANCE: invention relates to method for preparing carvedilol of the formula (I) , its optically active R- or S-enantiomers, mixtures of these enantiomers and their pharmaceutically acceptable addition salts. Method involves interaction of 4-oxyranylmethoxy-9H...

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Hauptverfasser: BARKOTSI JOZHEF, RATKAI ZOLTAN, GREGOR TAMASH, DOMAN IMRE, NAD' KALMAN, CHELEN'JAK JUDIT, SHIMIG D'JULA, BALAZH LASLO, GREFF ZOLTAN, NEMET NORBERT, SHERESH PETER, DONAT VERETSKEI D'ERD'I, SABO TIBOR, KOTAI NAD' PETER
Format: Patent
Sprache:eng
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Zusammenfassung:FIELD: chemical technology, pharmacy. SUBSTANCE: invention relates to method for preparing carvedilol of the formula (I) , its optically active R- or S-enantiomers, mixtures of these enantiomers and their pharmaceutically acceptable addition salts. Method involves interaction of 4-oxyranylmethoxy-9H-carbazole or its R- or S-enantiomers with N-[2-(2-methoxyphenoxy)ethyl]benzylamine in proton organic solvent and prepared benzyl-carvedilol is debenzylated by reaction of catalytic hydrogenation. Method allows increasing economical indices at the yield 80%. EFFECT: improved preparing method, enhanced yield. 4 cl, 13 ex