METHOD FOR PREPARING 4,5,6,7-TETRACHLORO-2',4',5',7'-TETRAIODOFLUORESCEIN SODIUM SALT LABELED WITH IODINE RADIONUCLIDES

FIELD: organic chemistry, chemical technology, medicine. SUBSTANCE: method for preparing indicated end product involves the following stages: isolation of 4,5,6,7-tetrachloro- 2',4',5',7'-tetraiodofluorescein from dye Bengal pink, its purification, heterogenous isotope exchange o...

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Hauptverfasser:	ALEKSEEV E.G, KONEVA T.V, KORSAKOVA L.N, KORSAKOV M.V, GUSEL'NIKOV V.S, MOSTOVA M.I
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	FIELD: organic chemistry, chemical technology, medicine. SUBSTANCE: method for preparing indicated end product involves the following stages: isolation of 4,5,6,7-tetrachloro- 2',4',5',7'-tetraiodofluorescein from dye Bengal pink, its purification, heterogenous isotope exchange of iodine-127 in it using radioactive iodine and potassium iodate in hydrochloric acid-ethanol medium for 15- 20 min at 20 C. Method provides increase of radiochemical yield above 5% and enhancement of radiochemical purity of the end product. Method can be used for large-scale production and safety with respect to ecology. 4,5,6,7-Tetrachloro-2',4',5',7'-tetraiodofluorescein sodium salt labeled with iodine radionuclides represents pharmaceutical preparation for diagnostic aims and can be used in radionuclide diagnosis and topographic-anatomical investigations of liver state. EFFECT: improved preparing method, valuable medicinal properties. 1 tbl, 2 ex