MODIFIED FACTOR VII

FIELD: medicine, hematology. SUBSTANCE: invention relates to proteins used as anti-coagulating agents, in part, to modified forms of Factor VII inhibiting blood coagulation and tissue factor. Invention claims methods for different using, in part, for suppression of platelets depositions in the patie...

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Hauptverfasser:	PETERSEN LARS KHRISTIAN, BERKNER KEHTLIN L, KHART CHARLZ EH, KHEDNER ULLA, BREGENGOR KLAUS
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine, hematology. SUBSTANCE: invention relates to proteins used as anti-coagulating agents, in part, to modified forms of Factor VII inhibiting blood coagulation and tissue factor. Invention claims methods for different using, in part, for suppression of platelets depositions in the patient and treatment of acute occlusion of coronary artery. Invention relates also to composition consisting of Factor VII with at least one modification in its active site being this modification inhibits capacity of modified factor VII to activate plasmatic Factor X or IX significantly. Invention provides preparing the preparation without unwanted adverse effects and it can be prepared by recombinant method easily. EFFECT: valuable medicinal properties of factor VII. 23 cl, 18 tbl, 15 ex