ORTHO-SUBSTITUTED BENZOYLGUANIDINES AND MEDICINAL AGENT BASED ON THEREOF

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel ortho-substituted benzoylguanidines of the formula (I) wherein R(1) means hydrogen atom, alkyl with 1-8 carbon atoms, a, b, c = 0; one of two substituents R(2) and R(3) means O-CO-R(27) and another, respectively, among substit...

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Bibliographische Detailangaben
Hauptverfasser:	LANG KHANS JOKHEN, KLEEMANN KHAJNTS-VERNER, SHVARK JAN-ROBERT, SHOL'TS VOL'FGANG, AL'BUS UDO, BRENDEL' JOAKHIM, VAJKHERT ANDREAS
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel ortho-substituted benzoylguanidines of the formula (I) wherein R(1) means hydrogen atom, alkyl with 1-8 carbon atoms, a, b, c = 0; one of two substituents R(2) and R(3) means O-CO-R(27) and another, respectively, among substituents R(2) and R(3) means R(1); R(27) means alkyl with 1-8 carbon atoms; R(4) means hydrogen atom, alkoxy-group with 1-4 carbon atoms, fluorine, chlorine, bromine, iodine atoms; R(5) means hydrogen atom, and their pharmaceutically acceptable salts. Invention relates also to medicinal agent eliciting inhibitory activity with respect to Na+/H+- exchange and containing compound of the formula (I) and special additional additives. Compounds of the formula (I) are used for preparing a medicine for treatment or prophylaxis of diseases induced by ischemic states, infarction, stenocardia and so on. Invention provides preparing novel compounds eliciting inhibitory activity with respect to Na+/H+-exchange. EFFECT: valuable medicinal properties of compounds. 17 cl, 3 ex