LIGANDS FOR MELANOCORTINE RECEPTORS

FIELD: organic chemistry, peptides, pharmacy. SUBSTANCE: invention relates to novel cyclic peptides of the general formula (I): wherein B is a bridge group; E is hydrogen atom, halogen atom, -NO2, -NR8R8' or OR13; R8 and R8' each means independently hydrogen atom or methyl; R13 represents hydrogen atom or methyl; X means substituents by phenyl ring taken among hydrogen, halogen atom, -NO2 or -OR8; Z is one or more substituents by phenyl ring taken independently among hydrogen atom, halogen atom, -OR9 or two groups of Z can be taken to form the condensed aryl ring; R9 is hydrogen atom or methyl; D is ; , substituted or unsubstituted imidazolyl; R2, R3, R4, R5 each represents hydrogen atom, methyl or any two radicals among R2, R3, R4, R5 can bind to form heterocyclic or heteroaryl ring; p = from 1 to 3. Invention relates also to pharmaceutical composition eliciting selectivity with respect to receptors of MC-3 and/or MC-4 as compared with other melanocortine receptors. EFFECT: valuable medicinal properties of compounds. 13 cl, 33 ex