DERIVATIVES OF 8-SUBSTITUTED=9H-1,3-DIOXOL[4,5-H][2,3]- BENZODIAZEPINE AS INHIBITORS OF AMPA/KAINATE RECEPTOR, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT

FIELD: organic chemistry, medicine, neurology, pharmacy. SUBSTANCE: invention relates to novel derivatives of 8-substituted-9H-1,3-dioxol[4,5-h] [2,3] benzodiazepine of the formula (I) , method for preparing these compounds and pharmaceutical compositions comprising these active substances. Compound...

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Hauptverfasser:	EHD'ED ANDRASH, BARKOTSI JOZHEF, KOVACH ATTILA, LEVAI D'ERD', RATKAI ZOLTAN, GACHAJI ISHTVAN, DOMAN IMRE, CHELEN'JAK JUDIT, SHIMIG D'JULA, BALAZH LASLO, GREFF ZOLTAN, SHNEJDER GEZA, SHERESH PETER, VEG MIKLOSH, D'ERT'JAN ISHTVAN, SHIMO ANNAMARIJA, GIGLER GABOR, KOTAI NAD' PETER, TIKHAN'I KAROJ, SABO GEZA, SABADOSH TAMASH
Format:	Patent
Sprache:	eng ; rus
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Zusammenfassung:	FIELD: organic chemistry, medicine, neurology, pharmacy. SUBSTANCE: invention relates to novel derivatives of 8-substituted-9H-1,3-dioxol[4,5-h] [2,3] benzodiazepine of the formula (I) , method for preparing these compounds and pharmaceutical compositions comprising these active substances. Compounds of the formula (I) inhibit AMPA/kainate receptors. In compound of the formula (I) X means carbonyl or methylene group; Y means hydrogen atom or methyl group or in common with R3 it forms valence bond; R1-R3 mean values as given in the invention claim. Invention relates also to method of treatment of patients with epilepsy or neurodegenerative diseases. Invention provides preparing novel compounds eliciting the curative effect that allows to use them in medicine. EFFECT: improved preparing method, valuable medicinal properties of compounds and composition. 13 cl, 5 tbl