PEPTIDE FAMILY ELICITING NEUROTROPIC PROPERTY

FIELD: organic chemistry, peptides, amino acids, medicine. SUBSTANCE: invention relates to peptides of the general formula: A-B-C-D-Pro-Gly-Pro-X where A means 0, -Met(0), -Met, -Thr, -Ala, - Lys, -Gly, -Glu, -Arg, -His, -Phe, -Tyr, -Trp; B means 0, -Glu, -Lys, - Tyr, -Gly, - Arg, -Val, -pro; C mean...

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Bibliographische Detailangaben
Hauptverfasser:	MJASOEDOV N.F, KAMENSKIJ A.A, ASHMARIN I.P, SEREDENIN S.B, GRIVENNIKOV I.A, DUBYNIN V.A, ALFEEVA L.JU, ANDREEVA L.A, NEZAVIBAT'KO V.N, KOZLOVSKAJA M.M, LEVITSKAJA N.G
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, peptides, amino acids, medicine. SUBSTANCE: invention relates to peptides of the general formula: A-B-C-D-Pro-Gly-Pro-X where A means 0, -Met(0), -Met, -Thr, -Ala, - Lys, -Gly, -Glu, -Arg, -His, -Phe, -Tyr, -Trp; B means 0, -Glu, -Lys, - Tyr, -Gly, - Arg, -Val, -pro; C means 0, -His, -Pro, -Asp, -Gly, -Arg, - Tyr, -Val, -Phe; D means 0, -Phe, -His, -Arg, -Lys, - Ala, -Tyr, -Thr, - pro, -Ile; X means 0, -Ile eliciting neurotropic activity (0 means absence of amino acid) under condition that peptides: Glu-His-Phe-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Tyr-Pro-Phe-Pro-Gly-Pro-Ile and Met- -Glu-His-Phe-Pro-Gly-Pro are excluded. These compounds are useful as neurotropic preparations for correction of neuro-psychical fatigues, enhancement of adaptive capacity of human body under extreme conditions and in different pathologies of central nervous system including psychical diseases. EFFECT: enhanced effectiveness and valuable medicinal properties of peptides. 3 cl, 12 tbl, 1 dwg