NOVEL STREPTOGRAMINS, METHOD FOR THEIR PREPARING, NUCLEOTIDE SEQUENCES, POLYPEPTIDES AND PHARMACEUTICAL COMPOSITION

FIELD: biotechnology, antibiotics, pharmacy. SUBSTANCE: invention relates to novel streptogramins of the formula (I) and to method for preparing streptogramins by mutasynthesis using a mutated microorganism for alternation of biosynthesis of at least a single precursor of streptogramins. Invention d...

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Hauptverfasser:	DEBJUSSH LORAN, PARI ZHAN-MARK, FAMESHON ALAN, BAMA-ZHAK NATALI, BLANSH FRANSIS, BLAN VERONIK, KRUZE ZHOEHL, BAR'ER ZHAN-KLOD, DJUTRJUK-ROSSE ZHILL, TIBO DENI
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology, antibiotics, pharmacy. SUBSTANCE: invention relates to novel streptogramins of the formula (I) and to method for preparing streptogramins by mutasynthesis using a mutated microorganism for alternation of biosynthesis of at least a single precursor of streptogramins. Invention describes also nucleotide sequences and polypeptides taking part in biosynthesis of these precursors. Invention describes also pharmaceutical composition based on the claimed compounds and eliciting an antibacterial activity. EFFECT: improved preparing method, valuable medicinal properties of compounds. 40 cl, 13 dwg, 5 tbl