DERIVATIVES OF AMINOBENZOIC ACID, PHARMACEUTICAL COMPOSITION

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of aminobenzoic acid of the formula (1) or their pharmaceutically acceptable salts where A means -N(R5)-C(=Y1)-NR7R8 where Y2,R7,R9 are given in the invention claim; or A means -N(R5)-C(=NR7)Y2 where Y2, R7, R9 are given in the invention claim; or A means -N=C(NR8R2)NR8R7 where R2,R7,R8 are given in the invention claim; Z1 is given in the invention claim; V means -N(R6)- where R6 is taken among group including H, C1-6-alkyl; Y, Y3, Z and Z3 are taken independently among group including hydrogen atom, C1-6-alkyl; or Y and Z form in common C3-C6-cycloalkyl; R5 and R8 both mean hydrogen atom; n = 1; t means a whole number 0 or 1; p = 1; R means X-R3 where X means O-atom; R3 is given in the invention claim; R1 is given in the invention claim; R11 means H; or R11 in common with Y form pyrrolidinyl substituted with keto-group. New compounds show selective inhibitory activity with respect to alphavbeta3-integrins. Invention describes also pharmaceutical composition for selective inhibition of alphavbeta3-integrins comprising therapeutically effective amount of compound by any claim 1-11. EFFECT: valuable properties of compounds. 13 cl, 49 dwg