SUBSTITUTED CONDENSED HETEROCYCLIC COMPOUND, METHOD OF PHARMACOLOGICAL EFFECT, METHOD OF INHIBITION OF 5-LIPOXYGENASE ACTIVITY, INHIBITION OF LIPID PEROXIDES PRODUCTION OR BLOOD SUGAR LEVEL DECREASE

FIELD: chemistry of heterocyclic compounds, biochemistry. SUBSTANCE: invention relates to novel heterocyclic compounds of the formula (I) where R1 means group of the formula (II) ; R3 means 2,4-dioxothiazolidine-5-yl-methyl group and others; A means C1-6-alkylene group; B means oxygen atom; R4 means...

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Hauptverfasser: FUDZITA TAKASI, VADA KUNIO, FUDZIVARA TOSIKHIKO
Format: Patent
Sprache:eng
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Zusammenfassung:FIELD: chemistry of heterocyclic compounds, biochemistry. SUBSTANCE: invention relates to novel heterocyclic compounds of the formula (I) where R1 means group of the formula (II) ; R3 means 2,4-dioxothiazolidine-5-yl-methyl group and others; A means C1-6-alkylene group; B means oxygen atom; R4 means substituted phenyl or pyridyl that can comprise a substitute; R6 means hydrogen atom or C1-6-alkyl group; D means oxygen or sulfur atom; E means CH-group or nitrogen atom, or their pharmacologically acceptable salts. Invention relates also to method of pharmacological effect, method of inhibition of 5-lipoxygenase activity, inhibition of lipid peroxides production or decrease of blood sugar level. Invention can be used in medicine as therapeutic agent. EFFECT: valuable medicinal properties of compounds. 57 cl, 10 tbl