3-AMIDO-CHROMANYLSULFONYL(THIO)UREAS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to novel organic compounds, namely, to 3-amido-chromanylsulfonyl(thio)-ureas of the formula (I): where R(1) means hydrogen atom, alkyl with 1, 2, 3 or 4 carbon atoms, alkoxyl with 1, 2, 3 or 4 carbon atoms; R(2a), R(2b) and R(2c) are similar or distinct and mean hydrogen atom or alkyl with 1 or 2 carbon atoms; R(3) means hydrogen atom or alkyl with 1, 2, 3 or 4 carbon atoms; Z means sulfur or oxygen atom; A means unsubstituted phenyl or phenyl substituted with up to three similar or distinct substituted taken among group consisting of halogen atom, alkyl with 1 or 2 carbon atoms and alkoxyl with 1 or 2 carbon atoms; or A means residue of saturated or unsaturated lactam of the formula: where B means alkenylene or alkylene with 3, 4, 5 or 6 carbon atoms that is unsubstituted or substituted up to three similar or distinct alkyl groups with 1, 2, 3 or 4 carbon atoms; in all their stereoisomeric forms and as their mixtures taken in any ratios; and also their physiologically acceptable salts that are valuable medicinal active substances used for treatment of cardiovascular system disorders, especially for treatment of arrhythmia, for prevention of sudden heart stopping or for effect on decreased heart contractibility and also to method of their synthesis and pharmaceutical compositions containing thereof. EFFECT: synthesis of novel useful compounds, improved method of synthesis, valuable medicinal properties of compounds. 13 cl, 2 tbl, 23 ex