RECOMBINANT PLASMID DNA PAD5-F CARRYING OF ADENOVIRUS TYPE 5 GENOME FRAGMENT WITH DELETION IN GENE E1B-55K AND STRAIN OF MUTANT ADENOVIRUS ADE 12 EXHIBITING SELECTIVE ANTITUMOR ACTIVITY

FIELD: biotechnology, medicine, oncology, genetic engineering, molecular biology. SUBSTANCE: invention presents recombinant plasmid DNA pAd5-f and mutant strain of human adenovirus Ade 12. Recombinant plasmid DNA carries fragment of genome of adenovirus type 5 with deletion in gene E1B- 55K. Mutant...

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Hauptverfasser:	SOROKIN A.V, TERNOVOJ V.A, KISELEV S.L, KISELEV N.N, KACHKO A.V, SVJATCHENKO V.A, NETESOV S.V
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology, medicine, oncology, genetic engineering, molecular biology. SUBSTANCE: invention presents recombinant plasmid DNA pAd5-f and mutant strain of human adenovirus Ade 12. Recombinant plasmid DNA carries fragment of genome of adenovirus type 5 with deletion in gene E1B- 55K. Mutant strain of adenovirus obtained by homologous recombination using plasmid pAs5-f exhibits the selective antitumor activity. Strain can be used as a base for the development of effective antitumor preparation. EFFECT: valuable medicinal properties of strain and plasmid. 2 cl, 3 dwg, 2 tbl, 4 ex