BENZYLPIPERIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

BENZYLPIPERIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel 3-benzylpiperidines of the formula (I): where R1 means unsubstituted 2- or 3-indolyl, 5H-1,3-dioxolo-[4,5-f]-indolyl or said two compounds are substituted with groups: Hal, CN, AO, COOH or COOA; R2 means unsubstituted benzyl-...

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Hauptverfasser: BARBER EHNDR'JU, MARTINES KHOSEF-MARIJA, ZEJFRID KRISTOF, GRAJNER KHARTMUT, BETTKHER KHENNING, PRJUKHER KHEL'MUT
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel 3-benzylpiperidines of the formula (I): where R1 means unsubstituted 2- or 3-indolyl, 5H-1,3-dioxolo-[4,5-f]-indolyl or said two compounds are substituted with groups: Hal, CN, AO, COOH or COOA; R2 means unsubstituted benzyl- or phenylhydroxymethyl or said two compounds are substituted with groups: A, AO, Hal or CN where Hal means F, Cl, Br or J; A means C1-C10-alkyl; k = 0 or 1; m = 1, 2, 3 or 4 as racemic or separate steteroisomers and also their physiologically acceptable salts and solvents. Compounds of the formula (I) show effect on the central nervous system and present highly effective ligands of sigma-receptors and show strong inhibitory effect with respect to reuptake of 5-HT (serotonin). EFFECT: improved method of synthesis, valuable medicinal properties. 5 cl, 1 tbl, 16 ex