DERIVATIVES OF ISOXAZOLE AND CROTONIC ACID AMIDE

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel derivatives of isoxazole and crotonic acid amide of the general formula (I) where R1 means residue of the formula (II) or (III) ; R2 means O-(CH2)n-CH=CH2; n means a whole number 1-3, -O-(CH2)m-CH2-halogen; m means a whole num...

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Bibliographische Detailangaben
Hauptverfasser:	KIRSHBAUM BERND, SHVAB VILFRID, MJULLNER SHTEFAN
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel derivatives of isoxazole and crotonic acid amide of the general formula (I) where R1 means residue of the formula (II) or (III) ; R2 means O-(CH2)n-CH=CH2; n means a whole number 1-3, -O-(CH2)m-CH2-halogen; m means a whole number 1-3; halogen means fluorine, chlorine, bromine or iodine atom, residue of the formula (V) where R3 means halogen or NH2; R4 means hydrogen atom, and/or their physiologically acceptable salts. Invention relates also to derivatives of isoxazole and crotonic acid amide of the formula (IV) where R1 means residue of the formula (II) or (III); L means bridge link of group (a): -O-(CH2)n-CH2- where n means a whole number 1-3; (b): -NH-C(O)-CH(R4)(R3) where R3 means hydrogen atom; X means polymer or solid body. Compound of the formula (IV) can be used for detection of specifically bound proteins from cellular extracts, serum, blood or synovia, for protein purification, for modification of microtiter plates or for preparing chromatography material, especially affinity chromatography material. EFFECT: valuable properties of synthesized compounds. 7 cl, 3 tbl, 10 ex