ISOLATED DNA MOLECULE ENCODING GLUCAGON RECEPTOR, DNA-CONSTRUCTION, CELL LINE, METHOD OF PREPARING GLUCAGON RECEPTOR, ISOLATED GLUCAGON RECEPTOR PEPTIDE, ISOLATED ANTIBODY, PROBE, METHOD OF DETECTION OF GLUCAGON ANTAGONIST PRESENCE

molecular biology, medicine, endocrinology. SUBSTANCE: invention relates to glucagon receptors. Invention proposes the isolated DNA molecule encoding glucagon receptors or glucagon peptide receptors. DNA-construction provides expression of isolated DNA molecule and its insertion into cells of lines...

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Hauptverfasser:	KIDZHPER DZHOZEF L, O'KHARA PATRIK DZH, DZHELINEK LAURA DZH, SHEPPARD POL O, GRANT FREHNSIS DZH, LOK SI, KINDSVOGL VEHJN R, FOSTER DONALD S
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	molecular biology, medicine, endocrinology. SUBSTANCE: invention relates to glucagon receptors. Invention proposes the isolated DNA molecule encoding glucagon receptors or glucagon peptide receptors. DNA-construction provides expression of isolated DNA molecule and its insertion into cells of lines COS or BHK. Invention proposes also a method of preparing glucagon receptors involving culturing cell lines COS or BHK and isolation of the end product. Invention presents also a monoclonal antibody binding specifically with glucagon receptors and blocking glucagon binding with glucagon receptors. Invention relates to also a method of detection of glucagon antagonist involving agonist binding with isolated glucagon receptors. Invention can be associated with stimulation of glycolysis and glycogenolysis and study of glucagon role in diabetes mellitus etiology. EFFECT: improved method of preparing DNA, glucagon and peptide receptors. 13 cl, 5 dwg, 8 tbl