HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES AND METHODS OF THEIR SYNTHESIS

organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of 1,4-benzothiazepine- -1,1- dioxide of the formula (I) where R1 means unbranched C1-6-alkyl group; R2 means unbranched C1-6-alkyl group; R3 means hydrogen atom; R4 means phenyl; R5 R6, R8 are taken among hydrogen atom;...

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Hauptverfasser:	FAL'K OJGEN, EHNSEN AL'FONS, GLOMBIK KHAJNER, SHTENGELIN ZIGFRID
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of 1,4-benzothiazepine- -1,1- dioxide of the formula (I) where R1 means unbranched C1-6-alkyl group; R2 means unbranched C1-6-alkyl group; R3 means hydrogen atom; R4 means phenyl; R5 R6, R8 are taken among hydrogen atom; R7 means the group of formulas (Ia) and (Ib) where hydroxy-groups can be substituted with acetyl; R16 means -COOH, -CH2-OH, -CH2-O-acetyl, -COOMe; R9 and R10 are similar or different and each means hydrogen atom or C1-6/ -alkyl group; X means -O-, or to its salts, solvates and physiologically acceptable derivatives. Invention relates to also the compound of the formula (V) and methods of synthesis of these compounds. The proposed compounds inhibit absorption of bile acids and can be used as an active components of drug used for prophylaxis or treatment of patients with hyperlipidemic states. EFFECT: new compounds indicated above, improved methods of synthesis, valuable medicinal properties. 9 cl, 1 tbl, 5 ex