5-OXYMETHYL-5-[3-(2-CHLORETHYL)-3- NITROZOUREIDO]-2-CYCLOHEXYL- 1

medicine, veterinary science, oncology. SUBSTANCE: the method describes a novel compound 5-oxymethyl-5-[3- (2- chlorethyl)-3-nitrozoureido] -2-cyclohexyl-1.3- dioxane of formula I of antitumor activity. Compound I represents a highly active cytotoxic preparation of pronounced therapeutic effect upon...

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Bibliographische Detailangaben
Hauptverfasser:	STUKOV A.N, FILOV V.A, IVIN B.A, KON'KOV S.A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	medicine, veterinary science, oncology. SUBSTANCE: the method describes a novel compound 5-oxymethyl-5-[3- (2- chlorethyl)-3-nitrozoureido] -2-cyclohexyl-1.3- dioxane of formula I of antitumor activity. Compound I represents a highly active cytotoxic preparation of pronounced therapeutic effect upon all three strains of interwoven tumors investigated. Comparison for antitumor activity in both the suggested preparation and CCNU upon leukemic mice P-338 has demonstrated the superiority of the suggested compound. EFFECT: improved antitumor activity of biologically active compounds to be applied in treating tumors in mice and rats. 3 tbl, 4 ex