METHOD OF SYNTHESIS OF 1-PHENYL-2,3-DIMETHYL-4-IODOPYRAZOLONE-5 (IODOANTIPYRINE)
organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of 1- phenyl-2,3-dimethyl-4-iodopyrazolone-5 (iodoantipyrine) that a medicinal preparation. Invention proposes method of synthesis of iodoantipyrine by oxidative iodination of antipyrine in neutral medium in...
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| Zusammenfassung: | organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of 1- phenyl-2,3-dimethyl-4-iodopyrazolone-5 (iodoantipyrine) that a medicinal preparation. Invention proposes method of synthesis of iodoantipyrine by oxidative iodination of antipyrine in neutral medium in isopropyl alcohol used as an organic solvent. Use of the proposed method provides to obtain pharmacopoeia preparation of iodoantipyrine with quantitative yield. EFFECT: improved method of synthesis, increased yield, simplified process. 1 ex |
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