COVALENT CONJUGATES OF LIPIDS WITH PHOSPHONOCARBOXYLIC ACID, THEIR SYNTHESIS AND USE AS ANTIVIRAL MEDICINAL AGENTS

organic chemistry, pharmacy. SUBSTANCE: invention relates to phospholipid derivatives of phosphonocarboxylic acids of the formula (I) where R1 means the group -(CH2)eCyc1 where -(CH2)e means direct or branched saturated alkylene chain where e = 4-16; R2 means direct saturated alkyl chain with 1-20 carbon atoms; R3 means H or direct alkyl chain with 1-6 carbon atoms; X means sulfur atom; Y means oxygen atom; Cycl means cyclic alkyl moiety with 5-7 carbon atoms or phenyl that can be mono- or multisubstituted with C1-C10-alkyl, C1-C10-alkoxy-group or halogen atom; m = 0, 1-3 under condition that R1 can mean R2 if R2 means simultaneously R1, and to their physiologically acceptable salts. Invention describes also a medicinal agent containing the indicated compound as an active substance used for treatment of viral and among them retroviral diseases. EFFECT: improved method of synthesis, valuable antiviral properties of compounds. 11 cl, 4 tbl, 14 ex