AMIDOCARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHOD OF REDUCING GLUCOSE IN BLOOD

medicine. SUBSTANCE: described are new compounds of formula I wherein R1 is H, aryl; R2 is alkyl; R3 H, halogen, nitro group; R4 is H, alkyl, z is alkyl, w is alkyl, alkoxy, substituted aril, substituted heteroaryl where heteroatom is O, N, S and also substituted amino group and substituted oxy group; X is substituted aryl or substituted heteroaryl and where heteroatom is O, N,S. Compounds of formula I have hypoglykemic activity and are therefore useful as medicinal substituted aryl intended for lowering glucose level in blood. EFFECT: improved properties of the title compounds. 39 cl, 156 tbl medicine. SUBSTANCE: described are new compounds of formula I wherein R1 is H, aryl; R2 is alkyl; R3 H, halogen, nitro group; R4 is H, alkyl, z is alkyl, w is alkyl, alkoxy, substituted aril, substituted heteroaryl where heteroatom is O, N, S and also substituted amino group and substituted oxy group; X is substituted aryl or substituted heteroaryl and where heteroatom is O, N,S. Compounds of formula I have hypoglykemic activity and are therefore useful as medicinal substituted aryl intended for lowering glucose level in blood. EFFECT: improved properties of the title compounds. 39 cl, 156 tbl