INSULIN AND ITS DERIVATIVES WITH ENHANCED CAPACITY TO BIND ZINC

medicine, endocrinology, peptides, pharmacy. SUBSTANCE: invention describes derivatives of insulin of the general formula (I) where Z means histidine residue or peptide with 2-35 genetically encoded amino acid residues containing 1-5 histidine residues that show the enhanced capacity to bind zinc an...

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Hauptverfasser:	KHABERMANN PAUL, GAJSEN KARL, EHRTL JOKHANN, ZAJPKE GERKHARD
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	medicine, endocrinology, peptides, pharmacy. SUBSTANCE: invention describes derivatives of insulin of the general formula (I) where Z means histidine residue or peptide with 2-35 genetically encoded amino acid residues containing 1-5 histidine residues that show the enhanced capacity to bind zinc and useful for production of pharmaceutical compositions used for treatment of diabetic patients. Insulins of the formula (I) form complexes with zinc that contain insulin hexamer with about 5-9 moles of zinc per a hexamer. EFFECT: valuable properties. 16 cl, 11 ex