N-METHYL-N-[(1S)-1-PHENYL-2((3S)-3-HYDROXYPYRROLIDINE-1-Y1)-ETHYL]-2,2-DIPHENYLACETAMIDE

N-METHYL-N-[(1S)-1-PHENYL-2((3S)-3-HYDROXYPYRROLIDINE-1-Y1)-ETHYL]-2,2-DIPHENYLACETAMIDE

organic chemistry. SUBSTANCE: invention relates to N-methyl-N-[(1S)-1-phenyl-2- ((3S)-3-hydroxypyrrolidine-1-yl)-ethyl]-2,2- diphenylacetamide that can be used in treatment of patients with intestine inflammatory diseases. Compounds is synthesized by interaction of 1-[(1S)-3-hydroxypyrrolidine-1-yl]...

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Bibliographische Detailangaben
Hauptverfasser: KHOL'GER BEERES, SHTEFFEN NOJENFEL'D, INGE SHTEJN, EHNDRJU BARBER, KLAUS BBESHMANN
Format: Patent
Sprache:eng ; rus
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:organic chemistry. SUBSTANCE: invention relates to N-methyl-N-[(1S)-1-phenyl-2- ((3S)-3-hydroxypyrrolidine-1-yl)-ethyl]-2,2- diphenylacetamide that can be used in treatment of patients with intestine inflammatory diseases. Compounds is synthesized by interaction of 1-[(1S)-3-hydroxypyrrolidine-1-yl] -(2S)-2-methylamino-2- phenylethane solution cooled from -5 C to 10 C with diphenyl- -acetyl chloride in solvent in molar ratio of the parent reagent from 1:0.75 to 1:1.65, respectively, and in molar ratio of the parent reagents to solvent = (0.8-1.2):(0.9-1.3):(14-22). Crude product synthesized by this reaction is recrystallized in its warm state from solvent. Melting point of synthesized compound is 221-226 C. Compound synthesized by the proposed method is resistant thermodynamically. EFFECT: improved method of synthesis, valuable properties. 2 cl, 10 ex